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Handling4 min read

Storing peptides: lyophilisate, cold chain and stability

Direct answer

Lyophilised (freeze-dried) peptides are most stable as a powder, kept cool and dark. General laboratory practice is storage at −20 °C for the longer term, protected from light and moisture. Storage conditions are physical-chemical in nature and say nothing about application.

Form
Lyophilisate
Longer term
−20 °C
Avoid
Light & moisture

Why lyophilisate

Freeze-drying removes water to a dry powder. In that form degradation processes generally proceed more slowly than in solution, which benefits shelf life.

Temperature, light and moisture

For longer storage −20 °C is common; keeping it dark and dry helps against degradation. Repeated thawing and refreezing is avoided.

These are general principles of physical-chemical stability, not usage instructions.

What storage information is not

Storage conditions describe how a substance stays physically stable. They are not directions for use: all products are for research only.

References
  • ICH — Q1A(R2) — Stability Testing
  • Ph. Eur. — General texts on stability

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